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更新时间：2025-05-15
点击次数：416 肿瘤预防筛查检测方法
潘多姆检测（德国PanTum Detect）是通过检测巨噬细胞吞噬的全身肿瘤共有标志物 Apo10 和 TKTL1，来判断全身肿瘤组织病变的检测技术。 [1]
中文名
潘多姆检测
外文名
PanTum Detect
所属分类
肿瘤预防筛查检测方法
潘多姆检测有两大颠覆性技术创新：
首次发现全身肿瘤共有肿瘤标志物Apo10和TKTL1 [1]
Apo10是DNaseX的一段抗原表位，DNaseX在细胞凋亡过程中起关键作用 [2]
Apo10在细胞中累积，预示细胞凋亡受阻，细胞凋亡受阻是肿瘤组织病变的开端 [7]
Apo10检测值增高预示肿瘤/增殖性疾病的形成 [2]
TKTL1主要调节糖酵解代谢途径，在恶性肿瘤细胞中高表达与肿瘤的侵袭性、治疗抗性及预后等有密切关系。 [2]
TKTL1使肿瘤细胞通过糖酵解方式迅速代谢葡萄糖，产生能量并排出大量乳酸 [7]
TKTL1高表达，为肿瘤提供酸性环境，对抗免疫杀伤并增强肿瘤侵袭性 [7]
TKTL1促进核糖核苷合成并加速DNA复制，提高肿瘤细胞的治疗抗性 [7]
Apo10 and TKTL1 [1]
2. 首创基于巨噬细胞的检测实验体系 —— EDIM 检测实验体系 [1]
① 巨噬细胞能够主动到达全身所有病变组织，因此一次检测即可覆盖全身所有肿瘤。 [1]
② 巨噬细胞在肿瘤形成、发展各个阶段（癌前病变、原位癌、早期癌）均能主动的吞噬、富集样本，从而彻底解决了早期病变样本难以富集的难题。 [1]
③ 巨噬细胞具有极高灵敏度。 [1]
EDIM 检测实验体系
基于流式检测平台人工智能判读的检测流程
检测试验流程 [5]
判读标准 [5]
检测报告 [5]
在潘多姆检测达到阳性（AP-T≥260且Apo10≥140）时即视为肿瘤告警，有必要进行全身PET-CT检查，及时溯源定位。 [4]
1. 国内回顾性临床研究
中山大学肿瘤医院于2023年6月13日在欧洲《细胞肿瘤学》杂志发表研究成果，结论：APT在鉴别早期肺癌（原位癌和 I 期癌，占比81%）和肺结节及健康人群中，AUROC=0.9132 [2]
相关临床研究 [2]
相关临床研究 [2]
文献索引：Apo10 and TKTL1 in blood macrophages as biomarkers for differentiating lung cancer from benign lung lesions: a comparative study with conventional biomarkers. Xie, Chuanbo et al. Cell Oncol. (Dordrecht) 10.1007/s13402-023-00838-1. 2023. [2]
2. 国际前瞻性临床研究
2022年5月20日发表于欧洲《临床与医学影像杂志》 [3]
关键词：普通人群50-70岁；Apo10+TKTL1 ≥ 260 且 Apo10≥140 时进行 PET-CT；
恶性肿瘤定位
无葡萄糖摄取情况下形态学上明显的癌前肿瘤定位
有葡萄糖摄取情况下形态学上明显的癌前肿瘤定位
良性肿瘤定位
文献索引：Blood-test based targeted visualization enables early detection of premalignant and malignant tumors in asymptomatic individuals. Burg S, et al. J Clin Med Images (2022) 6(9). [3]
3.其他已发表国际临床研究文献
其他已发表国际临床研究文献 | |
序号 | 文献名称 |
1 | Apo10 and TKTL1 in blood macrophages as biomarkers for differentiating lung cancer from benign lung lesions: a comparative study with conventional biomarkers. Xie, Chuanbo et al. Cell Oncol. (Dordrecht) 10.1007/s13402-023-00838-1. 2023. [8] |
2 | Blood-test based targeted visualization enables early detection of premalignant and malignant tumors in asymptomatic individuals. Burg S, et al. J Clin Med Images (2022) 6(9). [9] |
3 | Biomarkers Apo10 and TKTL1: Epitope-detection in monocytes (EDIM) as a ew diagnostic approach for cholangiocellular, pancreatic and colorectal carcinoma, S. Saman Cancer Biomarkers 27 (2020) 129–137 [10] |
4 | APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression, Yang Li et al. Nat Commun. 2017, 10, 2502 [13] |
5 | EDIM-TKTL1/Apo10 Blood Test: An InnAP-Te Immune System Based Liquid Biopsy for the Early Detection, Characterization and Targeted Treatment of Cancer Johannes F. Coy Int. J. Mol. Sci. 2017, 18, 878 [11] |
6 | Analysis of circulating CD14D/CD16Dmonocyte-derived macrophages (MDMs) in the peripheral blood of patients with oral squamous cell carcinoma Martin Grimm et al. ORAL AND MAXILLOFACIAL PATH. 2016,03 [12] |
7 | A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells Martin Grimm et al. BMC Cancer 2013, 13:569 [14] |
8 | Diagnostic use of epitope detection in monocytes blood test for early detection of colon cancer metastasis Natalie Jansen, Johannes F. Coy Future Oncol. (2013) 9(4), 605–609 [15] |
9 | EDIM-TKTL1 blood test: a noninvasive method to detect upregulated glucose metabolism in patients with malignancies Oliver Feyen et al. Future Oncol. (2012) 8(10), 1349–1359 [16] |
10 | Lack of transketolase-like (TKTL) 1 aggravates murine experimental colitis Susanne Bentz et al. Am J Physiol Gastrointest Liver Physiol 300: G598–G607, 2011 [17] |
11 | Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells Xiaojun Xu et al. Int. J. Cancer: 124, 1330–1337, 2009 [18] |
12 | Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted S. Langbein et al. British Journal of Cancer 94, 578 – 585, 2006 [19] |
潘多姆检测技术可以更容易的识别癌前肿瘤或恶性肿瘤的风险，通过AP-T和Apo10数值来量化全身断全⾝肿瘤组织病变。
当潘多姆检测AP-T数值大于等于260且Apo10数值大于等于140时，预示着恶性肿瘤可能性较高，临床上多为原位癌或早期癌阶段。当AP-T数值大于等于260且Apo10数值小于140或AP-T小于260时，数值越高临床上预示组织病变程度越高，当AP-T越接近260时，不能完全排除少部分原位癌、早期癌。当AP-T数值小于240时，预示着存在恶性肿瘤的可能性较低。 [20]
参考资料
1
量化评估肿瘤病变程度！博鳌乐城成功引进潘多姆检测技术．乐城先行区管理局政府官微 [引用日期2023-08-10]
2
血巨噬细胞中APO10和TKTL1作为鉴别肺癌和良性肺癌的生物标记物:与传统生物标记物的比较研究．《细胞肿瘤学》杂志 [引用日期2023-08-10]
3
基于血液检测的靶向可视化可对无症状个体进行癌前肿瘤和恶性肿瘤的早期检测．临床与医学影像杂志 [引用日期2023-08-10]
4
Frontiers | Case Report: Early detection of lung carcinoid in an asymptomatic individual by blood-test initiated PET-CT imaging．《肿瘤学前沿》 [引用日期2023-08-28]
5
潘多姆检测技术介绍——全癌早筛，癌前预警．官网 [引用日期2023-09-15]
6
潘多姆检测技术成功通过进口审批，正式进入海南博鳌医疗先行示范区．光明网微博 [引用日期2023-09-22]
7
IJMS | Free Full．TKTL1/Apo10 Blood Test: An Innate Immune System Based Liquid Biopsy for the Early Detection, Characterization and Targeted Treatment of Cancer [引用日期2023-10-27]
8
Apo10 and TKTL1 in blood macrophages as biomarkers for differentiating lung cancer from benign lung lesions: a comparative study with conventional biomarkers. Xie, Chuanbo et al. Cell Oncol. (Dordrecht) 10.1007/s13402-023-00838-1. 2023.．《细胞肿瘤学》杂志 [引用日期2023-11-13]
9
Blood-test based targeted visualization enables early detection of premalignant and malignant tumors in asymptomatic individuals. Burg S, et al. J Clin Med Images (2022) 6(9).．临床与医学影像杂志 [引用日期2023-11-13]
10
Biomarkers Apo10 and TKTL1: Epitope-detection in monocytes (EDIM) as a new diagnostic approach for cholangiocellular, pancreatic and colorectal carcinoma．《癌症生物标志物》杂志 [引用日期2023-11-13]
11
EDIM-TKTL1/Apo10 Blood Test: An Innate Immune System Based Liquid Biopsy for the Early Detection, Characterization and Targeted Treatment of Cancer．临床应用液体活检特刊 [引用日期2023-11-13]
12
Analysis of circulating CD14+/CD16+ monocyte．ScienceDirect [引用日期2023-11-13]
13
APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression．自然通讯 [引用日期2023-11-13]
14
A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells．BMC癌症 [引用日期2023-11-13]
15
Diagnostic use of epitope detection in monocytes blood test for early detection of colon cancer metastasis Natalie Jansen, Johannes F. Coy Future Oncol．未来肿瘤学 [引用日期2023-11-13]
16
EDIM-TKTL1 blood test: a noninvasive method to detect upregulated glucose metabolism in patients with malignancies．未来杂志 [引用日期2023-11-13]
17
Lack of transketolase-like (TKTL) 1 aggravates murine experimental colitis Susanne Bentz．中国生物医学工程学报 [引用日期2023-11-13]
18
Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells．中国生物医学工程学报 [引用日期2023-11-13]
19
Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted S. Langbein．英国癌症杂志 [引用日期2023-11-13]
20
德国汉堡大学研究成果公布，早期癌症筛查可识别出无症状肿瘤患者．健康导报官方百家号 [引用日期2023-12-07]
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